Accurate power approximations for chi2-tests in case-control association studies of complex disease genes
نویسندگان
چکیده
منابع مشابه
On multi-marker tests for association in case-control studies
Genome-wide association studies (GWAs) have identified thousands of DNA loci associated with a variety of traits. Statistical inference is almost always based on single marker hypothesis tests of association and the respective p-values with Bonferroni correction. Since commercially available genomic arrays interrogate hundreds of thousands or even millions of loci simultaneously, many causal ye...
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PAWE-3D: visualizing power for association with error in case-control genetic studies of complex traits
UNLABELLED A website that plots power and sample size calculations over a range of up to eight parameters (including diagnostic misclassification error parameters) for two commonly used statistical tests of genetic association, the linear trend test and the genotypic test of association. AVAILABILITY This method is made available via the website http://linkage.rockefeller.edu/pawe3d/ CONTAC...
متن کاملTitle Robust Tests for Case-control Genetic Association Studies
May 10, 2010 Type Package Title Robust tests for case-control genetic association studies Version 1.03 Date 2010-05-10 Author Yong ZANG , Wingkam FUNG , Gang ZHENG Maintainer Yong ZANG Depends R (>= 2.6.0), mvtnorm Description This package supplies several robust tests for case-control genetic association studies. The te...
متن کاملLinkage, case-control association, and family-based association tests for complex disorders
We carried out an analysis of the Genetic Analysis Workshop 15 simulated Problem 3 data. We restricted ourselves to the present/absent phenotype. Linkage analysis revealed a very strong signal on chromosome 6. Association analysis revealed additional susceptible loci located on chromosomes 11 and 18. The latter two signals were subsequently verified with linkage analysis - but only after 20 rep...
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ژورنال
عنوان ژورنال: Annals of Human Genetics
سال: 2002
ISSN: 0003-4800,1469-1809
DOI: 10.1046/j.1469-1809.2002.00120.x